Yes, it is possible for maleimides with good aqueous solubility (like sulfo-Cyanine maleimides). If precipitation occurs, increase the mixture's organic co-solvent content to achieve better labeling. For more details, please check our protocol here.
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Is it feasible to use sulfo-Cyanine maleimide labels in distilled water?
Using distilled water for maleimide labeling.